کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9173994 1179968 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin
چکیده انگلیسی
S-1-P is released from activated platelets at sites of vessel injury and contributes to the development of intimal hyperplasia after bypass grafting, angioplasty, and stenting. S-1-P is a potent pro-migratory molecule for SMCs. Rapamycin is a commonly used immunosuppressive agent that has most recently been incorporated as the biologic agent in drug eluting stents with good success in the coronary circulation. Rapamycin inhibits the mammalian target of rapamycin, which, in turn, controls the translational mechanisms of the cell. The role of translational control during S-1-P-induced SMC migration is poorly understood. This study identifies a link between the mammalian target of rapamycin translational pathway and S-1-P and demonstrates how rapamycin might interfere with another facet of a vessel's response to injury after a vascular intervention, namely by interfering with the cell signaling of factors released from platelets deposited at the injury site.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Vascular Surgery - Volume 41, Issue 1, January 2005, Pages 91-98
نویسندگان
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