Poly(adenosine diphosphate ribose) polymerase inhibition modulates spinal cord dysfunction after thoracoabdominal aortic ischemia-reperfusion

Because paralysis caused by spinal cord ischemia remains a serious complication of thoracic aortic aneurysm repair, effective therapeutic strategies to prevent or decrease its incidence are desirable. Although there is hope that the systemic complications associated with open thoracic aortic aneurysm repair will be avoided by managing these lesions with catheter-based endovascular approaches, the initial experiences suggest that spinal cord ischemia might continue to be an unresolved clinical problem.