کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9175168 1179994 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Homocysteine promotes p38-dependent chemotaxis in bovine aortic smooth muscle cells
چکیده انگلیسی
This study demonstrates that homocysteine can promote chemotaxis of SMCs through a p38-dependent pathway. To our knowledge, this is the first report that homocysteine may influence SMC chemotaxis. It may be an important mechanism for homocysteine-induced atherogenesis, because the migration of SMCs from the media is believed to play a critical role in progressive intimal thickening. Although homocysteine promotes atherogenesis and thrombosis by a variety of mechanisms, the effects of homocysteine on SMC proliferation and migration might be critical elements that may have potential therapeutic implications, because selective blockade of the p38 pathway is feasible.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Vascular Surgery - Volume 41, Issue 3, March 2005, Pages 517-522
نویسندگان
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