کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9184603 | 1182828 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clinical presentation and laboratory diagnosis of heparin-induced thrombocytopenia
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Heparin-induced thrombocytopenia (HIT) type II is an immune mediated reaction in which pathologic antibodies develop to a complex composed of heparin and the platelet-derived alpha granule protein, platelet factor 4 (PF4). HIT must be recognized quickly so as to eliminate all heparin exposure from a patient's clinical care. Thrombosis (HITT) may accompany thrombocytopenia resulting in limb and life-threatening complications. Despite a higher incidence of subclinically detectable heparin-PF4 antibody formation in the cardiac care setting, the development of the full clinicopathologic syndrome occurs in approximately 2% to 3% of patients, similar to the incidence in other clinical scenarios.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Thoracic and Cardiovascular Surgery - Volume 17, Issue 1, Spring 2005, Pages 80-84
Journal: Seminars in Thoracic and Cardiovascular Surgery - Volume 17, Issue 1, Spring 2005, Pages 80-84
نویسندگان
Eleanor S. Pollak, Charles S. Abrams,