کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9201038 1189429 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of respiratory muscle training with CO2 breathing on cellular adaptation of mdx mouse diaphragm
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
The effect of respiratory muscle training with CO2 breathing on cellular adaptation of mdx mouse diaphragm
چکیده انگلیسی
The aim of our study was to investigate the cellular mechanisms induced by hypercapnic stimulation of ventilation, during 6 weeks/30 min per day, in 10 mdx and 8 C57BL10 mice (10±0.2 months old). Ten mdx and eight C57BL10 mice served as control group. This respiratory training increases in vitro maximal tetanic tension of the diaphragm only in mdx mice. Western blot analysis of diaphragm showed: (1) an over-expression of α-dystrobrevin in mdx and C57BL10 training group compared to control group (8100±710 versus 6100±520 and 2800±400 versus 2200±250 arbitrary units); (2) a decrease in utrophin expression only in mdx training group compared to control group (2100±320 versus 3100±125 arbitrary units). Daily respiratory muscle training in mdx mice, induces a beneficial effect on diaphragm strength, with an over-expression of α-dystrobrevin. Further studies are needed to determine if, in absence of dystrophin, the over-expression of α-dystrobrevin could be interpreted as a possible pathway to improve function of dystrophic muscle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuromuscular Disorders - Volume 15, Issue 6, June 2005, Pages 427-436
نویسندگان
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