Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples

► The interaction of rs157580 genotype and chronic family stress as a predictor of triglyceride levels was investigated in two independent Caucasian samples. ► Chronic family stress moderates the association between rs157580 genotype and triglyceride levels. ► G allele of rs157580 was associated with increased triglyceride levels among cases with family stress in both samples compared with A/A caregivers, but not among controls. ► Chronic family stress should be taken into account for disease risk assessment and intervention.