کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9211760 | 1197527 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of Macrophage Inflammatory Protein 3α in Human Inflamed Dental Pulp Tissue
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
دندانپزشکی، جراحی دهان و پزشکی
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چکیده انگلیسی
Severe pulpitis resulting from dental caries is characterized by marked inflammatory infiltrate such as lymphocytes. Little is known about the recruitment of these cells into the dental pulp lesions of carious teeth. Macrophage inflammatory protein-3α (MIP-3α), a CC chemokine attracts CC chemokine receptor 6 (CCR6)-expressing T cells. We examined the distribution of MIP-3α-positive and/or CCR6-positive cells in human inflamed and normal dental pulp by immunohistochemistry. MIP-3α was observed in all inflamed pulp sections, and was mostly distributed in macrophages that had accumulated in the area adjacent to carious lesions. Furthermore, CCR6 expression was also observed in the infiltrating lymphocytes. In contrast, MIP-3α and CCR6 were rarely detected in normal pulp. These findings suggest that MIP-3α plays a role in the advancement of pulpal inflammation via the recruitment of CCR6-expressing lymphocytes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Endodontics - Volume 31, Issue 2, February 2005, Pages 84-87
Journal: Journal of Endodontics - Volume 31, Issue 2, February 2005, Pages 84-87
نویسندگان
Tadashi DDS, PhD, Kanako DDS, Yoshitaka DDS, PhD, Tomohiko DDS, Hideaki DDS, PhD, Takashi DDS, PhD,