کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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921198 | 920759 | 2011 | 4 صفحه PDF | دانلود رایگان |
We examined the relationship between the personality trait of harm avoidance (HA) and the dopamine D2/3 receptor availability in striatal subdivisions using high resolution positron emission tomography (PET) with [11C]raclopride. Twenty-one healthy subjects completed 3 T magnetic resonance imaging and high resolution PET scans with [11C]raclopride in order to measure D2/3 receptor availability in subregions of the striatum. The D2/3 receptor availability was obtained on the basis of the Logan graphical method. The Temperament and Character Inventory was used to measure the biogenetic temperament of HA. The analysis revealed that the HA score had significant negative correlations with D2/3 receptor availability in the pre-commissural dorsal caudate and post-commissural putamen, suggesting that HA is associated with D2/3 receptor availability in the associative and sensorimotor subdivisions of the striatum, which are mainly involved in cognition and locomotion. Further research is required to determine if pathological states have similar dopaminergic mechanisms in specific striatal subdivisions.
► The temperament harm avoidance showed significant negative correlations with D2/3 receptor availability in the pre-commissural dorsal caudate and post-commissural putamen.
► The temperament of high HA may be associated with low levels of dopamine in the associative and sensorimotor subdivisions of the striatum.
► Variations in dopamine function in specific striatal subregions may influence the expression of certain behaviors in situations of high uncertainty and potential danger.
Journal: Biological Psychology - Volume 87, Issue 1, April 2011, Pages 164–167