کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
921579 920787 2008 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers
چکیده انگلیسی

Performance on the Sternberg working memory task, and MEG cortical response on a variation of the Sternberg task were examined in middle-aged carriers and non-carriers of the APOE ɛ4 allele. Physical activity was also assessed to examine whether exercise level modifies the relationship between APOE genotype and neurocognitive function. Regression revealed that high physical activity was associated with faster RT in the six- and eight-letter conditions of the Sternberg in ɛ4 carriers, but not in the non-carriers after controlling for age, gender, and education (N = 54). Furthermore, the MEG analysis revealed that sedentary ɛ4 carriers exhibited lower right temporal lobe activation on matching probe trials relative to high-active ɛ4 carriers, while physical activity did not distinguish non-carriers (N = 23). The M170 peak was identified as a potential marker for pre-clinical decline as ɛ4 carriers exhibited longer M170 latency, and highly physically active participants exhibited greater M170 amplitude to matching probe trials.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biological Psychology - Volume 78, Issue 2, May 2008, Pages 179–187
نویسندگان
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