TNFα, IFNγ and IL-10 gene polymorphisms in a sample of Sicilian patients with coeliac disease

Genetically determined higher frequencies of −308A tumour necrosis factor α and +874T interferon γ alleles, both in hetero and in homozygosis and mostly whether simultaneous, may play a role in predisposing to gluten intolerance. Subjects positive for −308A tumour necrosis factor α and +874T interferon γ alleles have an increased risk for coeliac disease.