کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9237774 1207847 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adhesion molecules in inflammatory bowel disease: Therapeutic implications for gut inflammation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Adhesion molecules in inflammatory bowel disease: Therapeutic implications for gut inflammation
چکیده انگلیسی
Mucosal endothelium has become one of the major areas of investigation in gut inflammation. It is now well recognised that it plays an active role in the pathogenesis of both forms of inflammatory bowel disease, Crohn's disease and ulcerative colitis, since endothelial cells regulate mucosal immune homeostasis, acting as “gatekeepers”, controlling leukocyte accumulation in the interstitial compartment. This process is mediated by leukocyte-endothelial adhesion molecules. This paper reviews the major molecules that mediate leukocyte-endothelial interactions, and summarises the results of the most recent clinical trials targeting adhesion molecules in inflammatory bowel disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 37, Issue 11, November 2005, Pages 811-818
نویسندگان
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