کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9242470 1209566 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Etiopatogenia de la esteatohepatitis no alcohólica
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Etiopatogenia de la esteatohepatitis no alcohólica
چکیده انگلیسی
The «double impact» theory is the most widely accepted explanation for the pathogenesis of non-alcoholic steatohepatitis, while insulin resistance is a key factor. In the «first impact » the increased afflux of fatty acids to hepatocytes combined with decreased triglyceride elimination and lower fatty acid oxygenation leads to steatosis. The steatosis is not always quiescent, since the accumulated fatty acids are susceptible to a «second impact» in which the following factors intervene: a) oxidative stress with an increase in the production of oxygen free radicals which activate transcription factors such as NF-κβ, facilitating the formation of cytokines (tumor necrosis factor-alpha, tumor growth factor beta 1, interleukin-8 and Fas ligands; b) lipid peroxidation with the formation of malondialdehyde and 4-hydroxynonenal, promoting the afflux of inflammatory cells to the liver, depleting antioxidants such as glutathione, inducing the formation of Mallory bodies and increasing collagen synthesis on activating stellate cells, and c) leptin, endotoxins and iron overload, which together induce the lesions of steatohepatitis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterología y Hepatología - Volume 28, Issue 7, September 2005, Pages 396-406
نویسندگان
,