کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9244006 | 1209898 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stimulated Active Potassium Secretion in a Patient With Colonic Pseudo-Obstruction: A New Mechanism of Secretory Diarrhea
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
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![عکس صفحه اول مقاله: Stimulated Active Potassium Secretion in a Patient With Colonic Pseudo-Obstruction: A New Mechanism of Secretory Diarrhea Stimulated Active Potassium Secretion in a Patient With Colonic Pseudo-Obstruction: A New Mechanism of Secretory Diarrhea](/preview/png/9244006.png)
چکیده انگلیسی
Background & Aims: Secretory diarrhea is caused by inhibition of intestinal active sodium absorption and stimulation of active chloride secretion. The resulting increase in fecal sodium salts causes an isotonic increase in fecal water output. Abnormalities in potassium transport are not known to be a cause of secretory diarrhea. The aim of our report is to describe a patient with secretory diarrhea that was mediated by excess intestinal secretion of potassium. Methods: A 78-year-old woman developed colonic pseudo-obstruction, complicated by severe diarrhea and hypokalemia. Her stools were collected quantitatively on 11 occasions and analyzed for electrolyte concentrations. Rectosigmoid potential difference was measured. Results: The diarrheal fluid had a very high potassium concentration (130-170 mEq/L) and a very low sodium concentration (4-15 mEq/L). Stool potassium losses were as high as 256 mEq/day (normal, 9 mEq/day), and fecal sodium losses were never higher than 13 mEq/day. Potential difference between colonic lumen and a peripheral reference electrode was â14 mV (lumen side negative). Conclusions: Fecal potassium salts were the exclusive driving force for severe secretory diarrhea in a patient with colonic pseudo-obstruction. The high fecal output of potassium was due to stimulation of active colonic potassium secretion, possibly because of changes in autonomic nervous system activity and distention of the colon in association with colonic pseudo-obstruction. The extremely low fecal excretion of sodium indicates that active sodium absorption was not inhibited. This case study reveals an ion transport mechanism of secretory diarrhea that has not been previously appreciated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 129, Issue 4, October 2005, Pages 1268-1273
Journal: Gastroenterology - Volume 129, Issue 4, October 2005, Pages 1268-1273
نویسندگان
Thomas G. Jr, Florentine C. Fuerst, Charles T. Richardson, Carol A. Santa Ana, Daniel E. Polter, John S. Fordtran, Henry J. Binder,