High-dose allopurinol for prevention of post-ERCP pancreatitis: a prospective randomized double-blind controlled trial

Pretreatment with high-dose, orally administered allopurinol decreases the frequency of post-ERCP pancreatitis. Despite the promising results of this prospective, randomized trial, further studies are needed to verify these observations before allopurinol can be recommended for routine clinical use.