کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
925253 1474027 2016 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuroanatomical correlates of verbal fluency in early Alzheimer’s disease and normal aging
ترجمه فارسی عنوان
ارتباطات نوروآمدومی در روانشناسی کلامی در ابتدای بیماری آلزایمر و پیری طبیعی
کلمات کلیدی
بیماری آلزایمر خفیف؛ روانی کلامی؛ از دست دادن ماده خاکستری؛ دژنراسیون ماده سفید؛ پیری طبیعی؛ بازیابی کلمه؛ VBM؛ DTI
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Mostly, brain–VF associations in aging and dementia are displayed in a continuum.
• Association between putamen/tectum and semantic accuracy differentiates AD patients.
• VF–brain correlations in AD show unique traits and features similar to normal aging.

Verbal fluency (VF) impairments occur early in Alzheimer’s disease (AD) and to a lesser extent also in normal aging. However, the neural underpinnings of these impairments are not fully understood. The present study evaluated whether VF impairments in early AD and normal aging rely upon common or different neuroanatomical correlates. We examined the association between VF performance and brain structure in 18 mild AD patients and 24 healthy elderly. Linear regressions were performed between accuracy and time intervals in VF scores and structural measurements of cerebral gray matter (GM) and white matter (WM) using MRI. Results showed that semantic VF correlated exclusively with GM in cerebellum, left temporal fusiform cortex, and WM in uncinate fasciculus, inferior fronto-occipital fasciculus and corpus callosum. Phonemic VF showed unique associations between intervals and WM in left-hemisphere tracts. The association between GM in hippocampus, subcortical structures and semantic accuracy differentiated patients from controls. Results showed that VF impairments are primarily associated with same structural brain changes in AD as in healthy elderly but at exaggerated levels. However, specific VF deficiencies and their underlying neural correlates exist and these clearly differentiate the initial stages of AD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Language - Volumes 155–156, April–May 2016, Pages 24–35
نویسندگان
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