Hemodynamic and electrophysiological connectivity in the language system: Simultaneous near-infrared spectroscopy and electrocorticography recordings during cortical stimulation

We applied near-infrared spectroscopy (NIRS) and electrocorticography (ECoG) recordings during cortical stimulation to a temporal lobe epilepsy patient who underwent subdural electrode implantation. Using NIRS, changes in blood concentrations of oxyhemoglobin (HbO2) and deoxyhemoglobin (HbR) during cortical stimulation of the left language areas were measured in each hemisphere. NIRS revealed that 2 Hz stimulation with 5 mA produced no significant hemodynamic changes in either hemisphere. By contrast, 50 Hz stimulation elicited significant increases in both HbO2 and HbR at the stimulation site. Furthermore, with 50 Hz stimulation of the left superior temporal gyrus, the increases in HbO2 and HbR were observed not only at the stimulation site but also concurrently at the left inferior frontal gyrus. This suggests the existence of functional connectivity in the language system. The present study demonstrates that simultaneous NIRS and ECoG studies during cortical stimulation allow a novel analysis of cerebral connectivity.

► Simultaneous NIRS and ECoG studies were performed.
► We measured hemodynamic changes during direct cortical stimulation.
► 50 Hz stimulation elicited both HbO2 and HbR increases at the site of stimulation.
► Concurrent remote hemodynamic responses were also detected.
► This suggests a site of as yet unidentified functional connectivity.