کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
925419 | 921490 | 2012 | 9 صفحه PDF | دانلود رایگان |

Patients with primary progressive aphasia (PPA) vary considerably in terms of which brain regions are impacted, as well as in the extent to which syntactic processing is impaired. Here we review the literature on the neural basis of syntactic deficits in PPA. Structural and functional imaging studies have most consistently associated syntactic deficits with damage to left inferior frontal cortex. Posterior perisylvian regions have been implicated in some studies. Damage to the superior longitudinal fasciculus, including its arcuate component, has been linked with syntactic deficits, even after gray matter atrophy is taken into account. These findings suggest that syntactic processing depends on left frontal and posterior perisylvian regions, as well as intact connectivity between them. In contrast, anterior temporal regions, and the ventral tracts that link frontal and temporal language regions, appear to be less important for syntax, since they are damaged in many PPA patients with spared syntactic processing.
► Left inferior frontal atrophy and dysfunction is associated with syntactic deficits in PPA.
► Posterior perisylvian cortex is also implicated.
► Syntactic processing is spared in patients with anterior temporal atrophy.
► Damage to dorsal but not ventral tracts is associated with syntactic deficits.
Journal: Brain and Language - Volume 122, Issue 3, September 2012, Pages 190–198