Comparison of hemispheric activation during mental word and rhyme generation using transcranial Doppler sonography

The Wada test is at present the method of choice for preoperative assessment of patients who require surgery close to cortical language areas. It is, however, an invasive test with an attached morbidity risk. By now, an alternative to the Wada test is to combine a lexical word generation paradigm with non-invasive imaging techniques. However, results of this approach are still not in complete agreement with the findings of the Wada test (r = .92; Knecht, Deppe, Ebner et al., 1998). We attempted to obtain a more distinct language lateralization with the development of a phonological rhyme generation paradigm based on pseudoword stimuli. To examine the predictive value of both paradigms we performed simultaneous bilateral functional transcranial Doppler ultrasonography on 19 right-handed male native German subjects. The rhyme generation condition produced a significantly stronger lateralization to the supposed hemisphere of language dominance than the classical word generation condition. The observed differences suggest that the rhyme generation paradigm is more robust in detecting hemispheric language dominance than other neuropsychological paradigms and might be most valuable for preoperative assessment of cortical language areas.