کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9308050 1249024 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of hemodialysis on protein metabolism
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های کلیوی
پیش نمایش صفحه اول مقاله
Effects of hemodialysis on protein metabolism
چکیده انگلیسی
Uremic malnutrition, as evidenced by decreased muscle mass, is strongly associated with increased risk of death and hospitalization events in chronic hemodialysis (CHD) patients. Several factors that influence protein metabolism predispose CHD patients to increased catabolism and loss of lean body mass. It has been long suspected that the hemodialysis (HD) procedure is a net catabolic event. Recent studies show that the HD procedure indeed induces a net protein catabolic state at the whole-body level as well as in skeletal muscle. There is evidence to suggest that these undesirable effects are caused by decreased protein synthesis and increased proteolysis. Animal studies suggest that decreased protein synthesis is likely mediated by the significant decrease in plasma amino acid concentrations during HD. On the other hand, increased protein degradation is, at least in part, mediated by the HD-associated inflammatory response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Renal Nutrition - Volume 15, Issue 1, January 2005, Pages 39-43
نویسندگان
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