Inhibition of prostasin expression by TGF-β1 in renal epithelial cells

Our findings indicate the possibility that TGF-β1 transcriptionally inhibits prostasin expression by the induction of IκBα and the subsequent inhibition of NF-κB/Rel activity in M-1 cells, and also suggest the possibility that TGF-β1 might inhibit sodium reabsorption through a reduction in prostasin expression and subsequent inhibition of ENaC activity.