Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts

These findings suggest a new cGMP- and GC-C-independent but PLA2-dependent signaling pathway for these peptides in the kidney. Most likely guanylin and uroguanylin inhibit luminal K+ channels of principal cells of human CCD via this pathway. This depolarization of principal cells consequently reduces the driving force of Na+ and water reabsorption, explaining natriuresis and diuresis caused by these peptides.