کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9317197 | 1251523 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A 1-year study to compare the hemostatic effects of oral contraceptive containing 20 μg of ethinylestradiol and 100 μg of levonorgestrel with 30 μg of ethinylestradiol and 100 μg of levonorgestrel
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
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![عکس صفحه اول مقاله: A 1-year study to compare the hemostatic effects of oral contraceptive containing 20 μg of ethinylestradiol and 100 μg of levonorgestrel with 30 μg of ethinylestradiol and 100 μg of levonorgestrel A 1-year study to compare the hemostatic effects of oral contraceptive containing 20 μg of ethinylestradiol and 100 μg of levonorgestrel with 30 μg of ethinylestradiol and 100 μg of levonorgestrel](/preview/png/9317197.png)
چکیده انگلیسی
The direction and magnitude of the changes (increase or decrease) in most of the hemostatic variables were similar in both treatment groups. The majority of changes of all investigated variables remained within the reference ranges of variation. The procoagulatory variables increased to some extent from baseline to treatment cycle 13, while the anticoagulatory variables slightly decreased. In particular, thrombin turnover measured by prothrombin fragments 1+2 increased during treatment by 35% in the 20 μg of EE group and by 38% in the 30 μg of EE group. Statistically significant differences between the two treatment groups were found only for TAT. For the profibrinolytic variables, plasminogen was increased by 42% (20 μg of EE) and 49% (30 μg of EE). While the plasma levels of tPA antigen were reduced during treatment, the levels of its activity were increased by 54% (20 μg of EE) and 20% (30 μg of EE). For PAI, both antigen and activity were decreased, somewhat more pronounced with 20 μg of EE. d-Dimer remained virtually unchanged. Finally, the median FbDP levels were elevated by 30% (20 μg of EE) and 38% (30 μg of EE).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contraception - Volume 72, Issue 2, August 2005, Pages 98-104
Journal: Contraception - Volume 72, Issue 2, August 2005, Pages 98-104
نویسندگان
Jørgen Jespersen, Jan Endrikat, Bernd Düsterberg, Werner Schmidt, Christoph Gerlinger, Jens Wessel, Johannes J. Sidelmann, Sven O. Skouby,