کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9317314 1251544 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The contractile phenotype of peritubular smooth muscle cells is locally controlled: possible implications in male fertility
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
The contractile phenotype of peritubular smooth muscle cells is locally controlled: possible implications in male fertility
چکیده انگلیسی
The contractile activity of peritubular tissue is responsible for the propulsion of spermatozoa along the lumen of seminiferous tubules toward the hilum of the testis. This function is performed by specialized contractile cells [peritubular smooth muscle cells (PSMC)] in response to the locally produced agonist, endothelin (ET). Here, we review current information on the complex ET-mediated control of peritubular contractility. In addition, we report new data demonstrating that the relaxant peptide adrenomedullin is produced by Sertoli cells and interferes with ET-mediated contraction of PSMC. Given the relevance of the seminiferous tubule sperm output for male fertility, the detailed definition of the mechanisms controlling peritubular contractility could contribute in different ways to novel therapeutic opportunities and provide potential targets for contraceptive strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contraception - Volume 72, Issue 4, October 2005, Pages 294-297
نویسندگان
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