کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9319031 | 1252324 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phosphodiesterase Type-5 Inhibitors: A Critical Comparative Analysis
ترجمه فارسی عنوان
مهار کننده های فسفودی استراز نوع 5: یک مقایسه تطبیقی انتقادی
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
چکیده انگلیسی
Considering the pharmacokinetic profile tadalafil distinguishes itself from sildenafil and vardenafil by its long half-life (T1/2=17.5Â h) resulting in the majority of patients in successful coitus attempts even after 112 days. As a rule of thumb the clinical efficacy of the respective PDE5 inhibitors corresponds pretty well to the 2.5-3-fold half-life time. In terms of onset of action as mirrored by the Tmax vardenafil has the shortest one (40Â min) followed by vardenafil (60Â min) and tadalafil (120Â min) As efficacy and side-effects may be differently perceived in the same individual patient with each of the three PDE5 inhibitors it seems reasonable to grant the couples the opportunity to try all drugs sequentially.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: EAU Update Series - Brought to you by:Anil Neerukonda Institute of Technology and Sciences 'Renewal due by 31 Dec 2017'
Journal: EAU Update Series - Brought to you by:Anil Neerukonda Institute of Technology and Sciences 'Renewal due by 31 Dec 2017'
نویسندگان
Hartmut Porst,