Appropriate Castration with Luteinising Hormone Releasing Hormone (LHRH) Agonists: What is the Optimal Level of Testosterone?

LHRH agonists have been thought to achieve an almost 100% of response in the initial therapy. Several studies have shown that when using a more stringent definition of castration, treatment with current LHRH agonists does not achieve this goal. As a consequence, measurement of testosterone should regain attention for evaluating treatment response to LHRH agonists as well as for monitoring breakthroughs and acute-on-chronic responses.