Effect of dehydroepiandrosterone on central and peripheral levels of allopregnanolone and β-endorphin

Dehydroepiandrosterone administration in ovariectomized animals increased allopregnanolone and β-EP central and peripheral levels, which suggests that this compound may play a role as a neuroendocrine mediator, possibly substantiating the beneficial effects of postmenopausal DHEA therapy on the central nervous system.