Oral feeding and nasal instillation immunization with Microtus brandti lactate dehydrogenase c epitope DNA vaccine reduces fertility in mice via specific antibody responses

The immune responses induced by Microtus brandti lactate dehydrogenase C4 DNA vaccine via oral feeding and nasal instillation in mouse were investigated. The number of newborns of the vaccinated mice was statistically significantly reduced compared with the control mice, but the vaccine failed to affect the birthrate, as all vaccinated mice gave birth.