Primary squamous cell carcinoma of the endometrium: a case report with immunohistochemical and molecular study

In summary, unlike the example reported in the literature by others, in the present case we demonstrated that PSCCE is not due to HPV infection, but probably to other pathogenetic mechanisms, which cause a mutation of p53 tumor-suppressor gene. Thus, it is reasonable to conclude that both HPV infection and unclear carcinogenic factors, responsible of p53 tumor-suppressor gene mutation, may cause PSCCE.