کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9334840 | 1256838 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Poor development of human nuclear transfer embryos using failed fertilized oocytes
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Poor development of human nuclear transfer embryos using failed fertilized oocytes Poor development of human nuclear transfer embryos using failed fertilized oocytes](/preview/png/9334840.png)
چکیده انگلیسی
Failed fertilized human oocytes from IVF were enucleated and used as recipients for somatic cell nuclear transfer. The reconstructed embryos frequently formed an expanded nucleus from the injected genome after activation. However, subsequent development beyond the 1-cell stage was poor, and the resulting embryos showed chromosomal abnormalities. Poor development of oocytes after nuclear transfer contrasted with that of control, sperm-injected oocytes, which often progressed to cleavage stages. These results suggest that failed fertilized oocytes are not effective recipients for somatic cell nuclear transfer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive BioMedicine Online - Volume 11, Issue 6, 2005, Pages 740-744
Journal: Reproductive BioMedicine Online - Volume 11, Issue 6, 2005, Pages 740-744
نویسندگان
Marie-Cecile Lavoir, Jingly Weier, Joe Conaghan, Roger A Pedersen,