کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9334962 1256853 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Five years' clinical use of GnRH antagonists: evaluation of safety and allergic potential
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Five years' clinical use of GnRH antagonists: evaluation of safety and allergic potential
چکیده انگلیسی
Three antagonists of gonadotrophin-releasing hormone are currently clinically available. Cetrorelix (Cetrotide®) and ganirelix (Orgalutran®/Antagon®) have been safely used in assisted reproduction since 1999 and 2000 respectively. The structurally similar abarelix (Plenaxis®) has been approved for the therapy of advanced androgen sensitive prostate cancer. However, due to the occurrence of allergic reactions, its use is restricted to only a subgroup of patients. These allergic side effects may not be due to abarelix, as the drug itself does not have a strong histamine liberating potential in vitro, but could be attributed to carboxymethylcellulose (CMC), which only Plenaxis, but not Cetrotide or Orgalutran/Antagon contain. CMC is used to obtain the sustained-release characteristics of Plenaxis. Since 1973, numerous case reports and studies have been published regarding allergic reactions and specific immunoglobulin E antibodies against CMC. Thus, the allergic side effects of Plenaxis could be rather due to CMC than to abarelix.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive BioMedicine Online - Volume 10, Supplement 3, 2005, Pages 61-65
نویسندگان
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