Growth factor deposition in anterior subcapsular cataract

Matrix components (ie, collagen types, fibronectin, fibrillin-1), as well as growth factors such as TGFβ1-LAP, TGFβ2, TGFβ3, FGF-2, and HGF-α, were detected in ASC. Fibrillin-1 might serve as a repository for TGFβs. These growth factors may modulate the phenotypic alteration and behavior of LECs. The MAP kinase cascade and TGFβ signaling are both activated in LECs in ASC.