کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9365410 | 1271506 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential gene expression in anaplastic lymphoma kinase-positive and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
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چکیده انگلیسی
Anaplastic large cell lymphoma (ALCL) is an aggressive large T- or null-cell lymphoma. Most ALCLs arising in children and young adults express a constitutively active receptor tyrosine kinase, anaplastic lymphoma kinase (ALK). Anaplastic large cell lymphomas lacking ALK are clinically heterogeneous and their pathogenesis is unknown. This study is the first complementary DNA (cDNA) microarray analysis using RNA extracted from tumor tissue (7 ALK+ ALCLs and 7 ALKâ ALCLs) to identify genes differentially expressed or shared between the ALK+ and ALKâ tumors. Unsupervised hierarchical clustering using the top 11 most statistically significant discriminator cDNAs correctly grouped all ALK+ and ALKâ tumors. Hierarchical clustering analysis using the 44 cDNAs with the greatest differential expression between ALK+ and ALKâ RNAs grouped 6 of 7 ALK+ ALCLs together and 1 ALK+ ALCL with the ALKâ group. In general, ALK+ tumors overexpress genes encoding signal transduction molecules (SYK, LYN, CDC37) and underexpress transcription factor genes (including HOXC6 and HOX A3) compared with the ALKâ group. Cyclin D3 was overexpressed in the ALK+ group and the cell cycle inhibitor p19INK4D was decreased in the ALKâ group, suggesting different mechanisms of promoting G1/S transition. Both groups had similar proliferation rates. Genes highly expressed in both ALKâ and ALK+ ALCLs included kinases (LCK, protein kinase C, vav2, and NKIAMRE) and antiapoptotic molecules, suggesting possible common pathogenetic mechanisms as well.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 36, Issue 5, May 2005, Pages 494-504
Journal: Human Pathology - Volume 36, Issue 5, May 2005, Pages 494-504
نویسندگان
Mary Ann MD, PhD, Jennifer MD, Sarah E. BS, Andreas MD, QiFu BS, Sandy PhD, Stephen J. MD, Jeremy BS, Xueqiong MS, Yu PhD, Marsha C. MD,