Rotavirus-induced murine biliary atresia is mediated by nuclear factor-κB

The authors found that occlusion of the EHBDs could be noted in pups after inoculation of 107 pfu RRV. Meanwhile, the expression of active NF-κB in the liver and in the EHBDs was increased after inoculation of RRV. Simultaneous intraperitoneal injection of PDTC, however, was shown to prevent the obstruction of EHBDs secondary to inoculation of RRV. These results show that the murine biliary atresia induced by RRV is mediated by active NF-κB.