The influence of the dopaminergic system on cognitive functioning: A molecular genetic approach

Results showed associations of the COMT gene with attention and with time estimation but most noteworthy was an interaction effect DRD2 × VAL on interference performance as measured by the STROOP-test explaining 13% of the variance. Findings suggest that a balance between DA related catabolic enzyme activity and receptor density are good predictors for the endophenotype of cognitive interference and that the COMT gene is in accordance with previous studies related to cognitive functioning.