کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9406651 1290133 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats
چکیده انگلیسی
The aim of the present study was to investigate the effects of NMDA receptor blockade on formation of object recognition memory. In the first experiment, adult Wistar rats were given an intraperitoneal injection of saline or the NMDA receptor antagonist [(+)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]cyclo-hepten-5,10-imine-maleate] (MK-801) (0.001, 0.01, or 0.1 mg/kg) 20 min prior to training in a novel object recognition task. In the second experiment, saline or MK-801 (0.1 mg/kg) were given immediately after training. Memory retention was tested 1.5 and 24 h after training. MK-801 impaired both short- and long-term retention of object recognition memory when given either before or after training. The results suggest that NMDA receptor activation is necessary for formation of object recognition memory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 156, Issue 1, 6 January 2005, Pages 139-143
نویسندگان
, , , , ,