کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9406651 | 1290133 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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![عکس صفحه اول مقاله: Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats](/preview/png/9406651.png)
چکیده انگلیسی
The aim of the present study was to investigate the effects of NMDA receptor blockade on formation of object recognition memory. In the first experiment, adult Wistar rats were given an intraperitoneal injection of saline or the NMDA receptor antagonist [(+)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]cyclo-hepten-5,10-imine-maleate] (MK-801) (0.001, 0.01, or 0.1Â mg/kg) 20Â min prior to training in a novel object recognition task. In the second experiment, saline or MK-801 (0.1Â mg/kg) were given immediately after training. Memory retention was tested 1.5 and 24Â h after training. MK-801 impaired both short- and long-term retention of object recognition memory when given either before or after training. The results suggest that NMDA receptor activation is necessary for formation of object recognition memory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 156, Issue 1, 6 January 2005, Pages 139-143
Journal: Behavioural Brain Research - Volume 156, Issue 1, 6 January 2005, Pages 139-143
نویسندگان
Maria Noêmia M. de Lima, Daniela C. Laranja, Elke Bromberg, Rafael Roesler, Nadja Schröder,