کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9409376 | 1613302 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nitric oxide pathway is an important modulator of heat loss in rats during exercise
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
To assess the role of nitric oxide (NO) in central thermoregulatory mechanisms during exercise, 1.43 μmol (2 μL) of NÏ-nitro-l-arginine methyl ester (l-NAME, n = 6), a NO synthase inhibitor, or 2 μL of 0.15 M NaCl (SAL, n = 6) was injected into the lateral cerebral ventricle of male Wistar rats immediately before the animals started running (18 m minâ1, 5% inclination). Core (Tb) and skin tail (Ttail) temperatures were measured. Body heating rate (BHR), threshold Tb for tail vasodilation (TTbV), and workload (W) were calculated. During the first 11 min of exercise, there was a greater increase in Tb in the l-NAME group than in the SAL group (BRH = 0.17 ± 0.02 °C minâ1, l-NAME, versus 0.09 ± 0.01 °C minâ1, SAL, p < 0.05). Following the first 11 min until â¼40 min of exercise, Tb levels remained stable in both groups, but levels remained higher in the l-NAME group than in the SAL group (39.16 ± 0.04 °C, l-NAME, versus 38.33 ± 0.02 °C, SAL, p < 0.01). However, exercise went on to induce an additional rise in Tb in the SAL group prior to fatigue. These results suggest that the reduced W observed in l-NAME-treated rats (10.8 ± 2.0 kg m, l-NAME, versus 25.0 ± 2.1 kg m, SAL, p < 0.01) was related to the increased BHR in l-NAME-treated animals observed during the first 11 min of exercise (r = 0.74, p < 0.01) due to the change in TTbV (39.12 ± 0.24 °C, l-NAME, versus 38.27 ± 0.10 °C, SAL, p < 0.05). Finally, our data suggest that the central nitric oxide pathway modulates mechanisms of heat dissipation during exercise through an inhibitory mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 67, Issues 1â2, 30 September 2005, Pages 110-116
Journal: Brain Research Bulletin - Volume 67, Issues 1â2, 30 September 2005, Pages 110-116
نویسندگان
Ana Cristina R. Lacerda, Umeko Marubayashi, Cândido C. Coimbra,