کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9409442 | 1613303 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
3D modelling, gene expression mapping and post-mapping image analysis in the developing human brain
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کلمات کلیدی
DRGMGEOPTCarnegie stageLGEDPCTelencephalondorsal root ganglion - گانگلیون ریشه پشتیHuman - انسانolfactory epithelium - اپیتلیوم بویاییlateral ganglionic eminence - برجسته گانگلیونی جانبیlateral ventricle - بطن جانبیForebrain development - توسعه فرامرزOptical Projection Tomography - توموگرافی پیش بینی نوریdays post conception - روزه مفهومSpinal cord - طناب نخاعیcerebral cortex - قشر مغزmedial ganglionic eminence - میانه گانگلیونیChoroid plexus - پیوند کوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
As human brain development proceeds, there are complex changes in size and shape, most notably in the developing forebrain. Molecular technologies enable us to characterise the gene expression patterns that underlie these changes. To interpret these patterns the location of expression must be identified and, often, gene expression patterns compared for several genes or across several developmental stages. To facilitate interpretation we have generated a set of three-dimensional models using a recently developed technique, optical projection tomography. The models act as a framework onto which gene expression patterns are mapped and anatomical domains identified using custom-designed software, MAPaint. Here, we demonstrate their use to compare forebrain development at two embryonic stages (Carnegie stages 18 and 21; 44 and 52 days post conception, respectively) and as a means of recording, storing and visualising gene expression data for three example genes EMX1, EMX2 and OTX2. Anatomical domains were also mapped to the models and the comparison of gene expression and anatomical data is demonstrated at Carnegie stage 21. The three-dimensional models and sophisticated software facilitate the analysis and visualisation of morphological changes and gene expression patterns during early brain development and can be applied to the development of other complex structures.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 66, Issues 4â6, 15 September 2005, Pages 449-453
Journal: Brain Research Bulletin - Volume 66, Issues 4â6, 15 September 2005, Pages 449-453
نویسندگان
Subrot Sarma, Janet Kerwin, Luis Puelles, Mark Scott, Tom Strachan, Guangjie Feng, James Sharpe, Duncan Davidson, Richard Baldock, Susan Lindsay,