کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9409515 | 1290879 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Glutamate stimulation of acetylcholine release from myenteric plexus is mediated by endogenous nitric oxide
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Glutamate was found to be an excitatory neurotransmitter in the enteric nervous system. Although several lines of evidence indicate a role of glutamate in the regulation of gut motility and secretion the physiological significance of glutamatergic transmission is not clear yet. We studied the effect of glutamate on [3H]acetylcholine release and nicotinamide adenine dinucleotide phosphate-diaphorase staining in longitudinal muscle strips with attached myenteric plexus of guinea pig ileum. l-Glutamate (100 μM) significantly enhanced both the evoked [3H]acetylcholine release and the optical density of nicotinamide adenine dinucleotide phosphate-diaphorase positive neurones, i.e. the intensity of staining. The non-competitive N-methyl-d-aspartate receptor antagonist MK-801 (3 μM) abolished the stimulatory effect of l-glutamate on acetylcholine efflux. Similarly, the nitric oxide synthase inhibitor NÏ-nitro-l-arginine (100 μM) significantly reduced the effect of l-glutamate on [3H]acetylcholine release and nicotinamide adenine dinucleotide phosphate-diaphorase staining. Our data suggest that endogenous nitric oxide seems to mediate the stimulatory effect of glutamate on acetylcholine release from guinea pig myenteric neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 66, Issue 3, 15 August 2005, Pages 229-234
Journal: Brain Research Bulletin - Volume 66, Issue 3, 15 August 2005, Pages 229-234
نویسندگان
Elisaveta A. Milusheva, Vjara I. Kuneva, Dimitar E. Itzev, Nadejda I. Kortezova, Beata Sperlagh, Zlatka N. Mizhorkova,