کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9409543 | 1290881 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The neuroprotective efficacy of α-crystallin against acute inflammation in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Acute inflammation activates macrophages or monocytes and subsequently releases several inflammatory cytokines and reactive oxygen and nitrogen species. These proinflammatory cytokines activate astrocytes and trigger neurodegenerative diseases. In this work, we chose to address the mechanistic aspects of α-crystallin's protective function in inflammation-triggered neurotoxicity in mice. α-Crystallin, a lens structural protein, comprising α-A and α-B subunits is an ubiquitous molecular chaperone, which have been shown to reduce reactive oxygen species (ROS) production and enhance cellular glutathione level in the acute inflammation-induced mice. Results show that the proinflammatory cytokines such as interleukin-1α (IL-1α) and tumor necrosis factor-α (TNF-α) and nitric oxide (NO) were significantly high (P < 0.05) in the plasma, liver, cortex and hippocampus of inflammation-induced mice when compared to control. α-Crystallin pretreatment prevents inflammation-induced cytokines and NO production. In addition, a significant (P < 0.05) reduction of dopamine (DA), 5-hydroxytryptamine (5-HT) and norepinephrine (NE) was also observed in the inflammation-induced mice. Nevertheless, their metabolites, such as 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) increased significantly (P < 0.05) as compared to control. The results indicate that α-crystallin pretreatment controls the inflammation-induced DA, 5-HT and NE catabolism and suggest that α-crystallin has the potential to act as an anti-inflammatory agent in the neuroprotective processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 67, Issue 3, 15 October 2005, Pages 235-241
Journal: Brain Research Bulletin - Volume 67, Issue 3, 15 October 2005, Pages 235-241
نویسندگان
J. Gunasingh Masilamoni, S. Vignesh, R. Kirubagaran, E. Philip Jesudason, R. Jayakumar,