کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9409590 | 1290885 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
NMDA glutamate but not dopamine antagonists blocks drug-induced reinstatement of morphine place preference
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The effects of dopaminergic and glutamatergic antagonists on the drug-induced reinstatement of a previously extinguished morphine conditioned place preference (CPP) in mice were evaluated. Following extinction of a place preference induced by morphine (40Â mg/kg), a non-contingent injection of the dopaminergic antagonists SCH 23390 (0.125, 0.5Â mg/kg), raclopride (0.3, 1.2Â mg/kg), haloperidol (0.1, 0.2Â mg/kg) and the dopamine (DA) release inhibitor CGS 10746B (1, 10Â mg/kg) or glutamatergic NMDA antagonists memantine (10, 20, 40Â mg/kg) and MK-801 (0.1, 0.2, 0.3Â mg/kg) alone or with 10Â mg/kg morphine was given. Neither the dopaminergic nor the glutamatergic antagonists alone reinstated the place preference. Dopamine antagonists failed to block the morphine-induced reinstatement of place preference while memantine and MK-801 blocked it with intermediate and high doses. These results suggest that drug-induced reinstatement of place preference may be largely independent of dopamine and more closely related to glutamatergic neurotransmission.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 64, Issue 6, 30 January 2005, Pages 493-503
Journal: Brain Research Bulletin - Volume 64, Issue 6, 30 January 2005, Pages 493-503
نویسندگان
B. Ribeiro Do Couto, M.A. Aguilar, C. Manzanedo, M. RodrÃguez-Arias, J. Miñarro,