کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9415671 | 1614322 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuroanatomical evidence for participation of the hypothalamic dorsomedial nucleus (DMN) in regulation of the hypothalamic paraventricular nucleus (PVN) by α-melanocyte stimulating hormone
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کلمات کلیدی
cholera toxin β-subunitEndocrine and autonomic regulation - تنظیم غدد درون ریز و اتونومیکNeuroendocrine regulation: other - تنظیم نوروآندوکرین: دیگرdorsomedial hypothalamic nucleus - هسته هیپوتالاموس dorsomedialHypothalamic paraventricular nucleus - هسته پروبیالیک هیپوتالامیکalpha-melanocyte stimulating hormone - هورمون تحریک کننده آلفا ملانوستی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
To test the hypothesis that neurons in the hypothalamic paraventricular nucleus (PVN) may be under both direct and indirect regulation by alpha melanocyte-stimulating hormone (α-MSH)-synthesizing neurons of the arcuate nucleus, we determined whether the retrogradely transported marker substance, cholera toxin β-subunit (CtB), when injected into the PVN, labels distinct populations of neurons in the hypothalamic dorsomedial nucleus (DMN) that are innervated by axon terminals containing α-MSH. Following iontophoresis of CtB into the PVN, retrogradely labeled neurons were identified in the DMN primarily on the same side as the injection, although a few neurons were also identified in the opposite side of the DMN. The greatest percentage of retrogradely labeled DMN neurons were located in the medial portion of the ventral subdivision of the DMN (DMNv), accounting for approximately 64.8 ± 1.1% of all CtB-labeled cells in the DMN. The second largest population, comprising 25.9 ± 1.6% of the total number of CtB cells in the DMN, was diffusely distributed in the dorsal subdivision of the DMN (DMNd). Only 9.4 ± 0.3% of the CtB-labeled cells were located in the compact zone of the DMN (DMNc). In double-labeling immunofluorescent preparations, 61.1 ± 1.0% of the CtB cells in the DMNv, 38.6 ± 0.9% of the CtB cells in the DMNd, and 13.1 ± 1.3% of the CtB cells in the DMNc were contacted by axon terminals containing α-MSH. These data establish that neurons in discrete regions in the DMN may be influenced by the melanocortin signaling system and thereby, could serve as important relay sites to the PVN.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1064, Issues 1â2, 7 December 2005, Pages 42-51
Journal: Brain Research - Volume 1064, Issues 1â2, 7 December 2005, Pages 42-51
نویسندگان
Praful S. Singru, Csaba Fekete, Ronald M. Lechan,