کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9415837 | 1292945 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice](/preview/png/9415837.png)
چکیده انگلیسی
Mutant R406W human tau was originally identified in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) and causes a hereditary tauopathy that clinically resembles Alzheimer's disease (AD). In the current study, we examined the performance of R406W transgenic (Tg) mice in the forced swimming test, a test with high predictivity of antidepressant efficacy in human depression, and found an enhancement of the immobility time. In contrast, the motor function and anxiety-related emotional response of R406W Tg mice were normal. Furthermore, a selective serotonin reuptake inhibitor (SSRI), fluvoxamine (100 mg/kg, p.o.), significantly reduced this enhancement of the immobility time, whereas a noradrenaline reuptake inhibitor, desipramine, had no effect. In an in vivo microdialysis study, R406W Tg mice exhibited a significantly decreased extracellular 5-hydroxyindoleacetic acid (5-HIAA) level in the frontal cortex and also exhibited a tendency toward a decreased extracellular 5-hydroxytryptamine (5-HT) level. Moreover, fluvoxamine, which reduced the enhancement of the immobility time, significantly increased the extracellular 5-HT level in R406W Tg mice. These results suggest that R406W Tg mice exhibit changes in depression-related behavior involving serotonergic neurons and provide an animal model for investigating AD with depression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1059, Issue 1, 12 October 2005, Pages 7-12
Journal: Brain Research - Volume 1059, Issue 1, 12 October 2005, Pages 7-12
نویسندگان
Nobuaki Egashira, Katsunori Iwasaki, Akihiko Takashima, Takuya Watanabe, Hideyuki Kawabe, Tomomi Matsuda, Kenichi Mishima, Shozo Chidori, Ryoji Nishimura, Michihiro Fujiwara,