کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416004 | 1614328 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Abnormal expression of epilepsy-related gene ERG1/NSF in the spontaneous recurrent seizure rats with spatial learning memory deficits induced by kainic acid
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
PBSNeural nitric oxide synthaseERG1SOD1SNARETLEVTAnNOSSRSAMPANSFDABBSA - BSAbovine serum albumin - آلبومین سرم گاوDisorder of the nervous system - اختلال در سیستم عصبیSprague–Dawley - اسپراگ داولیkainic acid - اسید کرییکlong-term depression - افسردگی طولانی مدتspontaneous recurrent seizure - تشنج مجدد خودبخودlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP tyrosine hydroxylase - تیروزین هیدروکسیلازDopamine - دوپامینdiaminobenzidine - دیامینو بنزیدینsuperoxide dismutase 1 - سوپر اکسید دیسموتاز 1temporal lobe epilepsy - صرع لوب تمپورالEpilepsy: basic mechanisms - صرع: مکانیسم پایهphosphate buffer saline - فسفات بافر شورLTD - محدودventral tegmental area - ناحیه تگمنتوم شکمیN-ethylmaleimide-sensitive fusion protein - پروتئین همجوشی حساس به N-ethylmaleimide
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Previous epilepsy-related gene screen identified a spontaneous recurrent seizure (SRS)-related gene named epilepsy-related gene (ERG1) that encodes N-ethylmaleimide-sensitive fusion protein (NSF). To explore whether spatial learning memory deficits are relevant to SRS and whether hippocampal NSF expression is altered by SRS, we used the kainic acid (KA)-induced epilepsy animal model. SRS was monitored for 3 weeks after injection of a single convulsive dose of KA. KA-treated rats with SRS, KA-treated rats without SRS, and saline-treated rats were then measured in Morris water maze. In this spatial learning task, KA-treated rats with SRS performed poorer compared to those without SRS and those treated with saline. During the subsequent probe trials, KA-treated rats with SRS spent less swim path and time in the target quadrant but more swim path and time in the opposite quadrant, and showed fewer platform crossings. Moreover, in situ hybridization and immunohistochemistry showed that both ERG1/NSF mRNA and NSF immunoreactive expression were down-regulated in the CA1 and dorsal dentate gyrus cells (dDGCs) of the hippocampus, and interestingly, tyrosine hydroxylase (TH) immunoreactive dopamine (DA) neurons were lost in ventral tegmental area (VTA) in the KA rats with SRS. These data demonstrate that SRS impairs spatial learning memory and suggest that the down-regulation of NSF expression pattern in the hippocampus and the loss of DA neurons in VTA might contribute to the spatial learning memory deficits induced by SRS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1053, Issues 1â2, 16 August 2005, Pages 195-202
Journal: Brain Research - Volume 1053, Issues 1â2, 16 August 2005, Pages 195-202
نویسندگان
Shengming Yin, Zhuo Guan, Yiyuan Tang, Jie Zhao, Jaushyong Hong, Wanqin Zhang,