کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416046 | 1614329 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Altered nitric oxide synthase and PKC activities in cerebellum of gamma-irradiated neonatal rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Altered nitric oxide synthase and PKC activities in cerebellum of gamma-irradiated neonatal rats Altered nitric oxide synthase and PKC activities in cerebellum of gamma-irradiated neonatal rats](/preview/png/9416046.png)
چکیده انگلیسی
In this study, we show that one single dose of gamma-irradiation at birth induces an inhibition of the cerebellar calcium dependent nitric oxide synthase (NOS) activity, probably correlated to the motor abnormalities and the disarrangement in the cerebellar cytoarchitecture observed in adult rats. This decrease in calcium dependent NOS activity could be associated with an increased protein kinase C (PKC) activity. PKC inhibition partially restores calcium dependent NOS activity, indicating that PKC activity could be negatively modulating the catalytic activity of calcium dependent NOS. These findings suggest that a decrease in nitric oxide (NO) production and the related increase in PKC activity could be intracellular events that participate in the onset of motor and cerebellar abnormalities induced by postnatal gamma-irradiation at early stages of life.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1051, Issues 1â2, 27 July 2005, Pages 8-16
Journal: Brain Research - Volume 1051, Issues 1â2, 27 July 2005, Pages 8-16
نویسندگان
MarÃa A. Zorrilla Zubilete, Hugo RÃos, Dafne Magali Silberman, Laura Ruth Guelman, MarÃa Jimena Ricatti, Ana MarÃa Genaro, Luis MarÃa Zieher,