کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416254 | 1292963 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of 17β-estradiol on the spontaneous activity of substantia nigra neurons: Evidence for a non-genomic mechanism
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of 17β-estradiol on the spontaneous activity of substantia nigra neurons: Evidence for a non-genomic mechanism Effects of 17β-estradiol on the spontaneous activity of substantia nigra neurons: Evidence for a non-genomic mechanism](/preview/png/9416254.png)
چکیده انگلیسی
Clinical and experimental evidence suggests that female sex hormones (estradiol and progesterone) affect structures in the central nervous system that are involved in the control of movement. Using conventional electrophysiological techniques to record extracellular action potentials in the substantia nigra of urethane-anesthetized rats, it was found that microiontophoretic applications of 17β-estradiol were able to modify the spontaneous activity of nigral neurons. 17β-estradiol produced significant changes in the firing frequency (excitation and inhibition) and increased the rhythmicity of the majority of cells studied. These changes appear to be influenced by the sex and the hormonal status of the animal. Effects are of short latency and are not blocked by the administration of tamoxifen. We conclude that estradiol produces changes in the firing rate and discharge pattern of nigral cells in the urethane-anesthetized rat via a non-genomic mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1049, Issue 1, 5 July 2005, Pages 1-7
Journal: Brain Research - Volume 1049, Issue 1, 5 July 2005, Pages 1-7
نویسندگان
Arelis RosalÃa Torres-Hernández, Jesús Alberto González-Vegas,