کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416295 | 1614333 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuropeptide B immunoreactivity in the central nervous system of the rat
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کلمات کلیدی
Neurotransmitters, modulators, transporters and receptors - انتقال دهنده های عصبی، مدولاتورها، حمل کننده ها و گیرنده هاsubstantia nigra - توده سیاهBrainstem - ساقه مغزEdinger–Westphal nucleus - هستن Edinger-WestphalSupraoptic nucleus - هسته Supraopticarcuate nucleus - هسته قوسparaventricular nucleus - هسته پروژسترویکHypothalamus - هیپوتالاموسPeptides: anatomy and physiology - پپتیدها: آناتومی و فیزیولوژی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neuropeptide B immunoreactivity in the central nervous system of the rat Neuropeptide B immunoreactivity in the central nervous system of the rat](/preview/png/9416295.png)
چکیده انگلیسی
Neuropeptide B (NPB) is a recently identified endogenous ligand for the orphan G protein-coupled receptors GPR7 and GPR8. NPB mRNA is expressed in the human, rat, and mouse brain. With the use of an antiserum directed against the rat NPB, immunoreactivity to NPB (irNPB) was detected in several discrete areas of the hypothalamus and midbrain. In the hypothalamus, irNPB cells were present in the medial preoptic area and nucleus, ventromedial preoptic nucleus, retrochiasmatic nucleus, paraventricular hypothalamic nucleus, supraoptic nucleus, accessory neurosecretory nuclei, periventricular hypothalamic nucleus, dorsomedial hypothalamic nucleus, supraoptic retrochiasmatic nucleus, lateral hypothalamic area, posterior hypothalamic area, dorsal hypothalamic area, and zona incerta. A few irNPB perikarya were noted in the arcuate nucleus, whereas a dense network of nerve fibers was present in the median eminence. In the midbrain, irNPB somata were noted in the substantia nigra (compact, reticular, medial, and lateral parts), paranigral nucleus, ventral tegmental area, interfascicular nucleus, and dorsal raphe nucleus. Neurons in the Edinger-Westphal were strongly labeled. Labeled cells were not detected in the cortex, medulla oblongata, and spinal cord; few lightly labeled cells were occasionally seen in the hippocampus. Double labeling the hypothalamic sections with NPB antiserum and vasopressin or oxytocin antibody revealed that a population of vasopressin- but not oxytocin-immunoreactive cells was irNPB. Tyrosine hydroxylase-positive neurons in the midbrain, presumably dopaminergic, were irNPB. The distribution of irNPB neurons in several areas of the hypothalamus and midbrain together with the colocalization with vasopressin or tyrosine hydroxylase suggests that the peptide may subserve neuroendocrine, autonomic, and motor functions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1045, Issues 1â2, 31 May 2005, Pages 157-163
Journal: Brain Research - Volume 1045, Issues 1â2, 31 May 2005, Pages 157-163
نویسندگان
Siok L. Dun, G. Cristina Brailoiu, Keisuke Mizuo, Jun Yang, Jaw Kang Chang, Nae J. Dun,