کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416400 | 1292968 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed rats
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کلمات کلیدی
complete Freund's adjuvant - adjuvant دوست کاملAnalgesia - بیهوشیpertussis toxin - سموم سورافنیSensory Systems - سیستم های حسیAcupuncture - طب سوزنی Spinal cord - طناب نخاعیPain modulation: anatomy and physiology - مدولاسیون درد: آناتومی و فیزیولوژیRat - موش صحراییHyperalgesia - پردردی یا هایپرآلژزی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed rats Effects of pertussis toxin on electroacupuncture-produced anti-hyperalgesia in inflamed rats](/preview/png/9416400.png)
چکیده انگلیسی
Our previous study showed that electroacupuncture (EA) significantly attenuated hyperalgesia in an animal model of persistent inflammatory pain. The present study was designed to show if Gi/o protein is involved in EA-produced anti-hyperalgesia. Spinal Gi/o-protein function was destroyed by intrathecal pretreatment with pertussis toxin (PTX). Seven days after the placement of an intrathecal PE-10 tube, PTX was injected into the intrathecal space of the lumbar spinal cord of rats. Seven days after PTX, complete Freund's adjuvant (CFA) was injected into the plantar surface of one hind paw of the rat to induce hyperalgesia in the injected paw. EA treatment was given at acupoint GB30 immediately post-CFA and then hyperalgesia was assessed by measuring the degree of decreased paw withdrawal latency (PWL) to a noxious thermal stimulus. The results showed that PTX pretreatment prevented EA-produced anti-hyperalgesia in the CFA inflammatory pain model but did not affect either baseline pain threshold or CFA-induced hyperalgesia. The data suggest that EA-produced anti-hyperalgesia is mediated by PTX-sensitive Gi/o proteins and the relevant signaling pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1044, Issue 1, 17 May 2005, Pages 87-92
Journal: Brain Research - Volume 1044, Issue 1, 17 May 2005, Pages 87-92
نویسندگان
Bing Liu, Rui-Xin Zhang, Linbo Wang, Ke Ren, Jian-Tian Qiao, Brian M. Berman, Lixing Lao,