کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416423 | 1614334 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging
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کلمات کلیدی
In situ hybridization - Hybridization در محلNeurotransmitters, Modulators, Transporters, and Receptors - انتقال دهنده های عصبی، مدولاتورها، حمل کننده ها و گیرنده هاImmunohistochemistry - ایمونوهیستوشیمیRat brain - مغز موش صحراییWestern blot - وسترن بلاتExcitatory amino acid receptors: structure, function and expression - گیرنده های آمینواسیدی هیجان انگیز: ساختار، عملکرد و بیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging Expression of groups I and II metabotropic glutamate receptors in the rat brain during aging](/preview/png/9416423.png)
چکیده انگلیسی
Age-dependent changes in the expression of group I and II metabotropic glutamate (mGlu) receptors were studied by in situ hybridization, Western blot analysis and immunohistochemistry. Male Fisher 344 rats of three ages (3, 12 and 25 months) were tested. Age-related increases in mGlu1 receptor mRNA levels were found in several areas (thalamic nuclei, hippocampal CA3) with parallel increases in mGlu1a receptor protein expression. However, a slight decrease in mGlu1a receptor mRNA expression in individual Purkinje neurons and a decline in cerebellar mGlu1a receptor protein levels were detected in aged animals. In contrast, mGlu1b receptor mRNA levels increased in the cerebellar granule cell layer. Although mGlu5 receptor mRNA expression decreased in many regions, its protein expression remained unchanged during aging. Compared to the small changes in mGlu2 receptor mRNA levels, mGlu3 receptor mRNA levels showed substantial age differences. An increased mGlu2/3 receptor protein expression was found in the frontal cortex, thalamus, hippocampus and corpus callosum in aged animals. These results demonstrate region- and subtype-specific, including splice variant specific changes in the expression of mGlu receptors in the brain with increasing age.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1043, Issues 1â2, 10 May 2005, Pages 95-106
Journal: Brain Research - Volume 1043, Issues 1â2, 10 May 2005, Pages 95-106
نویسندگان
Agnes Simonyi, Richard T. Ngomba, Marianna Storto, Maria V. Catania, Laura A. Miller, Brian Youngs, Valeria DiGiorgi-Gerevini, Ferdinando Nicoletti, Grace Y. Sun,