کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416561 | 1292975 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Behavioral effects of 8-OH-DPAT injections into pontine and mesencephalic areas containing 5-HT-immunoreactive perikarya in the pigeon
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کلمات کلیدی
ANNnBORfasciculus longitudinalis medialisNIIISubstantia grisea centralisSCVEpendymaAVTMPVGCTFRMPAPFRLFLMSCDTPCBCDNIVRPOAvian - Avian یا آوین یا پرندگانaqueduct - آب جوش4th ventricle - بطن چهارمNucleus ruber - رشته هسته ایIngestive behaviors - رفتارهای بدخیمOculomotor nerve - عصب OculomotorNeural Basis of Behavior - مبانی عصبی رفتاریLoc - محلCerebellum - مخچهWater intake - مصرف آبfood intake - مصرف غذاEdinger–Westphal nucleus - هستن Edinger-Westphalraphe nuclei - هسته رافهnucleus of the basal optic root - هسته ریشه نورپردازی پایهnucleus reticularis pontis oralis - پل دهان هسته
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study examined the distribution of 5-HT-immunoreactive perikarya (5-HT-IRp) and the effects of local injections of 8-OH-DPAT into 5-HT-IRp-containing pontine and mesencephalic regions on feeding and drinking behaviors in free-feeding pigeons. When infused into the midline 5-HT-IRp-containing areas, 8-OH-DPAT (6.1 nmol) reliably elicited drinking and, to a lesser extent, feeding responses during the first hour after injection. These responses were significantly higher than the ingestive indexes observed (1) after vehicle (ascorbic acid 0.1%, 200 nl) injections at the same sites and (2) after 8-OH-DPAT injections into adjacent sites devoid of 5-HT-IRp. Increases in drinking were proportionally higher than those observed in feeding and a significant negative correlation was observed between water and food after midline 8-OH-DPAT injections. Similar dipsogenic responses were observed after injections of different 8-OH-DPAT doses (0.6, 2.0, and 6.1 nmol). Pretreatment with local injections of p-MPPI (an antagonist of 5-HT1A receptors) attenuated the ingestive responses evoked by 8-OH-DPAT injections. Injections of 8-OH-DPAT into lateral 5-HT-IRp-containing sites evoked only inconsistent and weak ingestive responses. These results indicate that 5-HT1A receptor-mediated circuits located in the midline superior raphe system of the pigeon may play an important role in mechanisms controlling water intake, similar to that observed in mammals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1035, Issue 2, 28 February 2005, Pages 154-167
Journal: Brain Research - Volume 1035, Issue 2, 28 February 2005, Pages 154-167
نویسندگان
Luciane P.N. Häckl, Graciela de Oliveira Richter, Moacir Serralvo Faria, Marta A. Paschoalini, José Marino-Neto,