کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416596 | 1614336 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Repeated stress alters caffeine action on motor coordination in C57Bl6/J male mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
This study was aimed to evaluate the effects of stress on caffeine action on motor coordination in mice. For 6 consecutive days, the mice were subjected to three different stressors. Saline or caffeine (30, 60 or 120 mg kgâ1) was i.p. administered after the last stressful experience, then the animals were behaviorally tested in the holeboard. Their stumbling frequency was compared to that of unstressed mice injected with either saline or caffeine. (1) There was a strong trend for stress to impair motor coordination. (2) In unstressed mice, caffeine induced a linear dose-dependent increase of stumbling frequency. (3) Stress decreased the stumbling frequency induced by the highest dose of caffeine. The results are discussed in terms of interaction of stress and caffeine on dopaminergic and GABAergic systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1039, Issues 1â2, 28 March 2005, Pages 171-176
Journal: Brain Research - Volume 1039, Issues 1â2, 28 March 2005, Pages 171-176
نویسندگان
L. Meyer, J. Caston,